September 24, 1988
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| Number 1 - Don't Worry Be Happy | Bobby McFerrin |
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| Number 2 - Sweet Child O' Mine | Guns N' Roses | 
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| Number 3 - I'll Always Love You | Taylor Dayne |
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| Number 4 - Simply Irresistible | Robert Palmer |
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| Number 5 - Love Bites | Def Leppard |
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| Number 6 - Perfect World | Huey Lewis & The News |
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| Number 7 - One Good Woman | Peter Cetera |
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| Number 8 - If It Isn't Love | New Edition |
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| Number 9 - Nobody's Fool | Kenny Loggins | 
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| Number 10 - Don't Be Cruel | Cheap Trick |